Southern Illinois University Edwardsville | SIUE SIUE is a nationally recognized university that provides students with a high-quality, affordable education that prepares them for successful careers and lives of purpose to shape a changing world. Built on the foundation of a broad-based, high-quality education, and enhanced by hands-on research and real-world experiences, the academic preparation SIUE students receive equips them to thrive in the global marketplace and make our communities better places to live.